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Background: Tamoxifen, a nonsteroidal estrogen antagonist, is the most prescribed drug for the treatment of breast cancer. The use of tamoxifen is limited, however, by the development of resistance to this compound in most patients. Although tamoxifen behaves primarily as an estrogen antagonist, it has agonist or growth-stimulatory activity as well. ICI , is a 7 alpha-alkylsulfinyl analogue of estradiol lacking agonist activity. The absence of agonist activity may make this steroidal antiestrogen superior to tamoxifen in suppressing tumor cell growth. Purpose: We compared the inhibitory effects of ICI ,, tamoxifen, and estrogen withdrawal on the growth of established tumors and on tumorigenesis in a model system that uses estrogen-dependent, human MCF-7 breast tumor cells growing in athymic nude mice. We also studied the hormonal responsiveness of tumors that became resistant to the two estrogen antagonists and the effects of these drugs on estrogen-regulated gene expression. Methods: MCF-7 cells were injected subcutaneously into the flanks of castrated, female nude mice.
If you can't do that, realizing that your partner may never come around to your side of things, you are not ready to marry this person. And I don't mean my good friend Satan. She doesn't want to marry you. The gold is in the footnotes and sources linked from those new essays. But I can't figure out whether or not we will ever get to that stage with the current situation and I'm scared of wasting my time waiting for things to get better. I too married for love but there's no emotional energy, support or empathy left for the darling wife. Yes, do sever the relationship.
